Abstract
Major histocompatabilty (MHC) proteins rely heavily on peptide backbone recognition for ligation. Nonetheless, modifications to the polyamide backbone of a tetrapeptide ligand can be made without abrogating binding.
MeSH terms
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Binding Sites
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HLA-DR1 Antigen / drug effects
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HLA-DR1 Antigen / metabolism
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Hemagglutinins / chemistry
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Histocompatibility Antigens Class II / drug effects*
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Histocompatibility Antigens Class II / metabolism*
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Inhibitory Concentration 50
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Lactams / chemistry
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Ligands
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Molecular Mimicry
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Molecular Structure
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Peptides / chemistry*
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Peptides / pharmacology*
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Phosphoproteins / drug effects
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Phosphoproteins / metabolism
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Structure-Activity Relationship
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Transcription Factors / drug effects
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Transcription Factors / metabolism
Substances
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HLA-DR1 Antigen
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Hemagglutinins
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Histocompatibility Antigens Class II
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Lactams
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Ligands
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Peptides
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Phosphoproteins
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Transcription Factors
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down-regulator of transcription 1